I've opened this girl and it seems that she has low self-esteem and is talking to me about it how nobody talks to her and she's out of place.I don't want to neg or C&F her because it think it's geniune and she isn't shit-testing me.
Would it be better for me to change the topic(I wouldn't know how to do this without ackwardness though) or how should I just continue talking to her about?

Yea, she basically just needs validation. She feels comfortable enough with you to open up, which is great. Now all you gotta do is show REAL interest in her, so she feels validated. Pretty simple.

1. So basically,no tricks,no negs or C&F just keep talking to her?
2. And how do I show REAL interest vs talking to her?
I've also noticed that she is quite difficult to have a conversation with(Which she previously told me)since she'll say nothing interesting is going on in her life and etc.how do I open the next time?

I often find shy girls attractive.

What I do is to listen to everything they say. Then I use it to validate them later on. My experience, is that it works a lot better this way, then to give them validation right away. Because you might come across as needy or trying to hard.

An example of what I did a last time:
Arn: what would you wanna be if you could choose whatever you wanted for a career.
Shy-HB: hmmm, maybe an actor.
Arn: why aren't you?
Shy-HB: I don't have the looks.
Arn: ok, bla bla bla... next routine...
----- Later ---- conversation drops silent, I look at her and smile.
Arn: I think you could definitely become an actor.

Another thing I do is; physical escalation, while still holding a normal conversation. We might be talking about cats or whatever. For everyone else around it looks like we're having a nice conversation, but simultaneously I will be stroking her thigh or back. This satisfy both her shy and comfortable "nice-girl" and her inner "bad-girl"(believe me, all girls have this side to them).

Good luck!
/arn

Thanks but regarding the first routine she's still a student and says she's not sure what she wants to do yet another problem is if I stroke her or do kino to that extent she's quite conservative and part of my social circle.

Anothing problem I get is that when talkng to her it feels like I keep asking questions and am carrying the conversation.Any thing to fix that?

dude, gaming lse girls is pretty much the easiest thing in the world. Shut off your inner pua. You dont need him. Stop thinking. Forget about negs, dhv's, c&f etc. If your a high value, non needy guy, just talking to her naturally should make her fall for you. I do recomend you still tease her from time to time but make sure its in a very playful way.

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There are 3 type of players, those who make it happen, those who watch it happen, and those who wonder what just happend. Which one are you?

All the above advice is very true. BUT you STILL should to qualify or there is a good chance (depending on HOW low self esteem she is) that she will not feel validated or will not feel like you actually like her...
Soooo, to answer you're question about how to show REAL interest:
Compliment her on things that she's mentioned about herself or things that you've noticed about her. Do you know how to qualify?

Is qualifying like eliciting values?
Or by qualifying you mean like using screening questions to test compliance?