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Don't use them just say hi and introduce yourself.
I will say PUA openers are somewhat counter productive to your growth as a PUA and more importantly as a man.
What these line do for you is offer a script or list of things you could say so when the time comes you can just walk up and say it without overthinking things or fumbling for words. A play book of lines to use if you will. There are a few serious problems with this though:
1. It avoids your real problems of natural confidence and delivery. In most cases it's not what you say but how you say it.
2. The delivery is often mechanical
3. It leaves you high and dry and fumbling for what to say after that line.
4. It's like pick up on training wheels. You keep it up you will never develop the natural skills you really need.
5. It keeps your confidence from growing because you will always be thinking "I need to use an opener every time I talk to a new girl". In turn this goes against the golden rule: don't put the girl up on a pedestal.
My best advice drop the pick up lines and openers and work on building you your confidence and working on natural delivery. Do this by observe something about the environment around he comment on it and strike up a conversation like you would with anyone else. This girl is hot sure but there is nothing special about her she is flesh and blood and has feelings.