I seem to have picked a lot of common threads to reply to, so I'll link to my explanation of how I deal with conversation topics again:
good-conversation-topics-for-clubs-vt44 ... highlight=
That's just what I do, I'm sure there are other ways too.
Man if a 10 just came up to you and said hi you basically just need to be fun and enjoyable! It seems to me that if you are just fun and exciting you could probably skip over a lot of the more hardcore PUA stuff and go straight for rapport. I mean, she's a 10, and she opened YOU. There's obviously attraction. I would just be cool, be fun, and work towards building rapport and comfort.
As for the relationship thing, I always wonder why guys of all people bring this up. If you want a relationship with a girl then just progress through what you would normally do in a relationship without addressing it. If things are going well, and you're rounding the bases at a normal speed, and you guys are mutually digging each other, then a relationship will form without a single awkward word being brought up about it. At some point it will probably be awkward NOT to talk about it, that's what you should go for.
Breaker