daggaz - Some good points to take on board. I suppose using them in a humerous way could actually work quite well. How the Beavis and Butthead thing worked i will never know

"I am Cornholio, I need piccata for my bunghole!" Can't see it working
Jaybot - It seems like it could work if used correctly. Could be funny and very effective if used with other techniques.
ID -
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i love using pick-up lines as a wing. this weekend, my buddy was gaming a target, i was dealing with her mother hen friend. i hear her say to him, "why do guys always insult (neg) me and think its flirting?" i walked over to them, and said, "thats not flirting, THIS is flirting" and proceeded to creepily inch over to her and drop a bad line or two. she laughed and forgot the whole thing in a second.
All i can say is awesome wingman demonstration. Shows that pick up lines can work in pick up, just not how most people would think.
samex - Great advice.
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These lines normally work, as a total ice breaker. Spin it off and ask her has that line ever worked on her. Or that you just heard some guy use and that girl across the room threw her drink at him.
Taking a pick up line and just adding another technique on the end. Opinion opener or situation style opener. Both would work well.