First off, my credentials. I've spent the last 5 years sarging in clubs. I've spent the last 2 years learning stuff from all the PUA masters, like Mystery, Strauss, DeAngelo, and Tyler Durgen. What I post is sum of all my experiences from trial and error and stuff I've learned from the masters which has helped me.

1. When approaching a chick at a night club, make sure you have an opener ahead of time. Don't rely on thinking of an opener on the spot. Very few men can make up an opener on the spot. Chances are you're not one of these guys. Spend some time before you go out think of a money opener. Remember, the opener doesn’t have to be perfect, just functional.

2. Most guys don't know what to do once they run their opener. They don’t know where to go. When you open, you have to be willing to keep the conversation going.
What most guys do is they open, and they expect the girl to carry the conversation at that point. This is a recipe for failure. Why would a girl want to keep talking to you when you haven’t shown any value? To her, there’s no difference between you and every other boring guy.
Tyler Durgen says you have to be willing to do 90% of the talking when you first open. This is true. So open, have them respond, and have something you can stack to so you ensure the conversation continues. Make sure you DHV during this process. Don't lean in. Talk with a loud, confident voice.

3. This is a great point I learned from Tyler. Lower your expectation of what comes out of your mouth. A lot of guys think they have to talk like James Bond in order to keep the girl interested. This is not true. Simply talk about whatever seems natural, but don’t talk about boring shit cause they’ve heard the boring stuff a million times before.

4. Stop caring what she thinks about you. Have you ever talked to a chick, and you get nervous because you're wondering what she thinks about you, and because you don't want to say something stupid you freeze up a bit? We'll, stop caring what she thinks about you. Just talk.
Try this exercise. Next time you go out, and you find yourself caring too much about what she thinks just mentally say. "Fuck this bitch" a few times in till you stop caring what she thinks about you. Remember you know nothing about her. She could be the world’s biggest slut. Why would you put this girl on a pedestal if she’s done nothing to earn your respect? Remember, you’ve approached her so that you can give her a shot at earning your respect.
(There is no girl out of your league. You’re the one putting her in this position)

5. Be cocky funny in your interaction (David DeAngelo) Bust on her. Most of the guys in the club kiss the girls ass when they talk. They have the same boring conversations with these girls like, “Where are you from or What do you do.” They have the same conversation with these girls that they would have with their dentist. Instead, try and talk to the girl like you'd talk to your best friend.
I don’t know about you, but my friends and I are always verbally making fun of each other.
The other day I was talking to a HB8. I could tell she was used to guys kissing her ass. During the conversation, she starting going on about her favorite Greek restaurant. The conversation was boring, so I pretended that I was falling asleep while she was talking. (How many guys do you think do this to her) She laughed and she hit me playfully. Then she said to my wing, "I hate your friend." Then I reeled her back in with "Awww, Your boring stories are great." And I hugged her to build kino. After the hug I immediately stacked and said, “Let me see your hands.” And I did the trust test routing. At this point I had her locked in. I ended up number closing.

6. Don't be afraid to push the limits. Don't be afraid to say things that might seem sexual, or rude. Don't over do it. But stop trying to be Mister Nice Guy. Push things a bit. She wants a guy that challenges her, and stands out. She doesn't want to talk to another boring guy.

7. When you’re in conversation, ask open ended questions or statements like:
How did that feel?
I bet that was shocking?
What was that like?
Watch the show Taxi Cab Confessions. The drivers are expects on having a full, natural sounding conversation with a minimal amount of talking. All they do is ask simple questions and the passengers are able to spill their guys. Girls like to talk, and asking the right questions will help the conversation flow.

So here’s the basic structure.

Example:
You(Opener): Hey, how do I talk my niece out of getting a tattoo. She’s only 16.
HBs. Blah Blah Blah
You: (Stacking) She’s going through this bad girl phase right now. The other day she calls me up and tells me that she’s in love with this boy at her school, but he’s like a total wanna be gangbanger. What is it with you girls and the wrong kinda guys? Why do you like them so much?
HBs: Blah Blah Blah
You: You guys are cool. You’re just like the View, only younger. How do you guys know each other?
HBs: Blah Blah Blah

At this point, they should be vested in enough to keep the conversation flowing. If the conversation starts to die you can try a Kino routine

great advices man! straight to the point, thanks.

kudos! always good to hear everyone's feedback from their experiences and very good pointers too!

Very good pointers Well done !

love the "fuck this bitch" idea...ha.