Hi Sebastian,
Hope things are going well for you! I don't think this has been asked before, and between us I'm not going to go through the posts either to check.

It'll be our secret. LOL.
You ask some good questions here and bring up some interesting points.
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When you go to websites like POF for example, which have the INTIMATE ENCOUNTER option... is it even worth messaging girls that have their profile listed in intimate encounters?
Yes I believe that messaging these girls can be helpful, however, it depends on what type of relationship you want in life. If you want a one night stand, dating, or friend with benefits this might work very well. It is possible to get into a sexual relationship and turn it into something long term but a little harder.
You mentioned that only about 20% of the girls even read your messages. I can state from a lot of online personal experience a lot of those people aren't checking their profile daily like you are. Many of them make one and then forget about it. That is a descent percentage but it can be improved upon.
We might need to look at what you're putting in the subject line and using for "interesting" material as far as openers go. But we'll get back to that later.
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Secondly, when you run across a profile that say stuff like "I like to be put in my place, fucked, licked, whole night, up the ass ETC ETC" you can't believe your eyes what you're reading... How do you message those girls?
Profiles that even makes sailors blush!

These types of girls are out there and they are available. The key here is not to bore them with bullshit. I get in the mindframe of the "caveman." They want a "man" that is going to pleasure them and can walk away. You will want to be very alpha, in control, and sexualize the conversation quickly in your messages to these type of people.
I wish you lots of luck and happy hunting! You can always change sites if this one isn't producing good results for you. I changed sites all the time when I was looking. Here are some others to think about.
Craigslist
Match
Singlesnet
Chemistry
Facebook
MySpace
Hope the information helps!