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All you guys who are against picking up your friends sister, you are missing the point of being a PUA. Almost all girls have brothers, it's almost certain you'll run into a girl with one at least once in your life. Overcoming them shouldn't be any different than overcoming your friends. Some are overprotective some are not. If you get that from a friend it's because they see something in you that he thinks may not a good thing to his sister.
In such cases your friend is a cockblock, and obviously you haven't completely earned their trust and need to do so.
Clearly as when approaching a group of people you need to open to their leader or the male in the group before you attract your target.
You don't break a man law, for the sake of pickup. If your friend is against you and his sister getting together, you have to respect his opinion. Even so, say you do hook up with her, and she becomes attached, you're going to fuck up the dynamic of your friendship with the whole family. So, unless she is worth all the bullshit you would have to deal with if it goes wrong, DON'T DO IT. And if you disagree with me, obviously you haven't been in the situation before, and I guess you'll have to learn the hard way.