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You may be negging too hard to the point of insult, like Chino said, and raising her defenses so high that she goes for a sticking point and like a frightened cornered mouse will lunge at a cat in a last ditch effort for survival, she is brutally reestablishing her Value Level.
Try negging less, try not caring, or keep doing it till you get told you're ugly to the point where you know you're wretched and that sticking point is just a callous and no longer hurts you thus you not caring any longer.
In all honesty, go over the dialog of these interactions, break down what happened just previous to her pulling this Ace of Spades out, and what led to it. Figure out if there was something that you can have judo'd her with.
This may be a good routine, your hideousness, that you can use to your advantage.
Try this:
"I have No idea why it matters what I look like since we all know that women don't really care about looks, they want a guy with a great personality and lots of money that can make them laugh. and all us guys want a dumb young virgin with great tits, but hey two out of three ain't bad, right? I mean that's why I'm still talking to you."
The stuff in bold is good, the rest is what you leave on the curb to be taken away buy the nice men in big trucks....garbage. Nothing like telling a girl you think she's shallow and wants you for your money (we're supposed to be keeping away from that and inspiring fun and passion) or telling her that you're just another pig who wants nothing more than to fuck a stupid Paris Hilton clone to make her completely unnattracted. Even if you deliver this amazingly, it's still gonna get filed away in her brain and she's gonna add it to your profile. The only exception to this, is if she is one of those girls who don't value themselves very highly and just like to get drunk and fuck random guys, then it'll probably be gold.