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Too many 'pua's' on here will tell you looks doesn't matter. It does.
This is not the debate here. Looks do make a difference, there is no question about that; but it's a bonus, nothing more. If you have model looks, of course you're gonna get a bit of a better chance than a guy who's spent a few too many nights in playing COD; however this is superficial, it doesn't matter how good looking you are, if you can't hold a conversation, eventually you WILL falter. You say you're a man of science, well so am I, science is based on fact or theorised fact, and the fact is that an extremely confident guy with average looks will always have as good chance, or better, than a guy with model looks but no confidence. Conversely just because you think a girl is incredibly attractive, doesn't mean SHE thinks she is; I've known plenty of girl that think they look buttfuck ugly but are actually hot as hell, no matter how many guys tell them they're hot, they still have their own insecure issues.
If you believe the contrary, that's your choice, but to tell OP not to even try is just being a dick quite frankly; it's ALWAYS better to try and fail then to give up and wonder would could've been with a little effort. You say "your direct opener will get shot down" who said anything about using a direct opener here? You're making assumptions about how other people run game because of a difference of opinion in one aspect. The fact of the matter is that Mystery Method, Annihilation Method, AFC Adam Meta Game, RSD and the rest are really no fucking different, they all get results for the guys who's style they best fit; MM won't work for me because I don't like to use routine after routine after routine, but the full on direct natural approach doesn't either, because I'm not 100% comfortable with it yet. So I use a combination that works best for MY personality.
In my opinion, the best pickup method is a matter of opinion that comes down to the individual, and all ANYONE on this site can offer in terms of advice, is either what they'd personally do in that situation, or what they have experienced usually works best for them in a similar situation.