It depends. I would say that it is possible to pick up any girl! Maybe not by using exactly the same routines for everyone but still. Attraction is universal, if you build a lot of attraction and comfort there is a good chance that something is gonna happen.
But circumstances make you win some and lose some, thats life.
She could be:
In a relationship with the love of her life.
Lesbian.
With her overprotective friends.
Mentally unstable.
A player.
Feeling depressed etc.
Religious (read the christian chick thread guys)
Or:
Into you.
Desperate.
Normal.
There are a million reasons why a girl may not respond to your game, you just have to learn to increase your success-fail ratio. For intelligent girls... I have gamed the elite of the intellectual world and it has worked as well as any club chick!