I tried this the other night off the top of my head (basically one of the guys I was hanging out with kept telling the girls I was a PUA, trying to blow my set, so I had to think on my feet and re-open the set.)
I think with a little polishing it could be not only a good opener, but can put across some DHV spikes too.
OK, so here's a more polished version than the one I used. Let me know your thoughts.
"Hey, guys. Let me get your opinion on something. When you have a glass of red wine do you hold the glass by the stem or the bowl? I can never remember the etiquette."
This can lead onto:
"I can only stay for a minute, I've gotta get back to my friends, but the reason I ask is a few weeks ago I took a friend of mine out to dinner at this classy restaurant. Anyway, the wine comes and she's giggling to herself as she watches me suffer with the waiters glaring at me in disapproval. In the end, I said to hell with it and just started drinking straight from the bottle

"
Like I say, I've only just thought of it, so it needs polishing, but I'd appreciate any feedback you have.
Cheers