Ok here's the deal, one of my main problems has always been that i'm a long time sufferer of male pattern blindness. Never had trouble getting attention from women it's just they could be practically lubing themselves up in front of me and I never got the signals. Which brings me to the point -

A couple months ago this very hot MILF starts coming in to my place of work, I'm immediately attracted to her (roughly 43, very hot, i'd say an 8... her arse is a 12) so at first i see her maybe every couple of weeks and every time she gives me some funny looks, as if i'm walking around with a dildo on my head.

Anyway one day she decides to strike up a conversation, just general fluff talk, (tease her about her flash car/mid-life crisis) which becomes a regular thing every couple of days. So long story short out of the blue I change jobs, a few days before I leave i see her one last time (not knowing this was the last time i'd see her) and she's particularly flirty, lots of intense eye contact, preening her hair, striking up conversation when it goes quiet and shows me a photo of herself in the local paper, makes a point of telling me it wasn't a professional photographer, just a co-worker messing around and follows up with a comment about how she looks better in the flesh, (really emphasises the word flesh!) like i said i don't really pay much attention at the time (male pattern blindness) but afterwards it occurs to me.

So a couple of weeks have passed and planning on going into the department store she works tomorrow, any good opener suggestions for this scenario?

Being a beginner with no real results, my advice shouldn't carry too much weight. I'll give you my thoughts, and you decide what they are worth.

Getting rid of your pattern blindness should be a higher priority than bagging this one woman, though it should be possible to get both. I have no idea how you'd fix the blindness though. I have been subject to it myself, in the past

When you enter the store, try to strike up a conversation for 2 minutes, keeping it flirty, playful and negging her. Then you "have to" go get whatever you need to get in the store, but get her number/E-mail before you go. Let her know you will be in touch "soon" (next 1-2 days) so you can get together for cofee and cookies to get to know each other better. If she is already as interrested as you think she is, it shouldn't be hard. I can't comment on whether 2-3 weeks is enough for her to have gone "stale" though (not enough experience).

Hope it works out. I am interrested in hearing what you do and how it turns out.