ok so i was at university today and was sitting with my two friends (both girls) and they were talking about how guys always tend to make whatever a girl says into something dirty and i started debating with them that girls have a dirty mind too.

So the opener could be something like:

"who has a dirtier mind, guys or girls?"

and most likely they gonna say guys so then you can ask them a funny question like
"what's long, hard and full of seamen?" (answer: submarine) to prove that they have a dirty mind lol and then tease them about it.

I think this would work best in a bar type scene. Anyways this is the first canned opener that i've come up with, i usually go situational but what do you guys think?

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it is better to be a lion for a day than a sheep all your life

lol it's funny, but personally I prefer ask smth about relationship or very strange question

"Do you think that men lie more than girls?"

"Can I have your opinion? a friend on mine is persecute from a girl in wheelchair who has a crush on him, how could he be polite to refuse her advances?"