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Don't use image manipulating software on your profile picture.
I agree with this as far a touch ups are concern. But not if you are alternating the picture to make it a totally different one. For example making the picture black and white where it was a color one before.
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Make sure you have a good view of your face. You want the people looking at the profile picture to have a mental image of you.
And your body if your main picture is of your whole body.
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Take the picture in an area that reflects the type of person you are trying to attract. If you want an athletic girl who loves hiking and what not. Take the picture outside.
I would say it is better to take pictures in areas that reflect who you are as a person. Not in areas that will attract the type of girls you want. Because even tho the girl may be into running, she may find a guy on a bike a lot more attractive or appealing than a picture of some guy running.