Yes, You can open with a Neg , but you might take a negative response.
In my opinion It depends on the situation but I think is better to use any opinion opener... and I'm basing this on the M3 (correct me if I'm wrong, please) but NEg's are used to put Bitch Shields off and to DHV and are used at A2 , and not on A1. Remember a C&F statement and NEGs aren't the same.
Anyway you can say anything , you could just say....
2 openers I just thought about:

Okay so you want to take a picture with me okay , I just love to take pictures with my Fans

(hold her and take a picture and just move on into something else. (tell a story, Ask her something , anything).

Hey this was our photo but anyway, Let me get your female opinion on something ...
You could also add something like , At least buy me a drink , you ruined an amazing photo with my friend
Bonus :

Okay now you owe me 5$ for the picture