Summary: Went out tonight to use Stelar's method and managed to try it on three sets. Got one number close, one instant "I have a boyfriend", and one that I ejected from after she told me her boyfriend works there.

The venue is bar/dance-club in the suburbs, frequented by cougars and local girls who don't feel like driving to the big city. Not a lot of high quality targets, but sets open easily. I dressed in a black suit-jacket, white dress shirt, nice jeans, and black shoes, well groomed, with a little stubble. I was in the club from 11:15 till about 1:00 when it died. I tried spotting attractive girls looking "idle", but there weren't many. I opened about 10 sets, mostly indirect. I'll just write up the 3 direct sets.

Set 1: Very first girl I opened was an Italian girl on the edge of the outside dance area, low-energy dancing and milling around with her friends.
I screw up my courage, and dive in.
Me: "Hey. I'm going to be open and honest with you, I think you're really sexy, and I want to get to know you.". Laser eyes.
Her: (smiles and touches hair) "Thank you!"
Me: (totally relieved, I break into a smile and go back into nice-guy mode... argh!!)
I pull her in to dance. She seems to be into me, getting cheek to cheek, but she won't let me escalate too much in front of her friends, and she won't let me isolate. We dance and talk for 10 minutes or so. She says they're going to be leaving soon, so I get her number and move on.

Set 2: Two of the better looking girls at the club had been sitting at the bar, and blowing off any guy that tried to talk to them. I started indirect on the cuter one.
Me: "Hey are you part of that group over there? (blah blah). So, I'm going to be really open and honest with you... etc"
Her: "I have a boyfriend"
Me: "That's ok, you can have a boyfriend, but I'm not going to apologize for what I want."
Her "ok".
I bail and never re-engage.

Set 3: A cute girl in a pink dress, standing alone and bouncing to the music by the bar near the inside dance floor.
Me: Grabs her hand and pulls her on the dance floor... "Come on... no, come on! You LOVE this song!"
Her: You're right, I DO love this song!
Me (while dancing): I'm going to be open and honest with you, I think you're really sexy and I want to get to know you."
Her: "Thanks!" starts dancing sexier, rubbing against me, smiling and making lots of eye contact.
Me: So who are you here with?
Her: My boyfriend's the DJ. (argh!!)
I eject.

Overall, the girls' response was positive. I'm going to try it some more and work being more consistently direct right from the open, not going into smiley nice-guy mode, and finding venues where "i think you're really sexy" isn't such a stretch.