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I either ignore their stupid comments, or reply back with " I've been on atibiotics" or now days I say it's something because of training related, I'm in decent shape now, often get asked to I swim etc, so I just waffle crap, because really it's small talk, so don't take it seriously!
I wouldn't make stuff up just to give them an understandable reason that you know isn't true as it will indirectly make you feel like you have to lie to fit in with them.
Also if people are with you and they know you don't drink because it is a conscious decision, but they hear you lying because you don't want to say the real reason. Surely that lowers value and has a more negative impact.
I understand the problem as you can't say "I don't drink because I'm running game on the girls in here" but you could still say something that is similar and true, something that will make you feel like you believe in why you don't drink "I do drink, just not as much as you, I end up making a fool of myself"
Something like that could make them laugh and agree with you, could be taken as a put down makeing you look more dominant. But more importantly it is something you believe and stand by.
Good luck may man!