So when I do isolate someone that i like, i try to pick a topic of interest and roll with it. usually can get maybe 10min of conversation in. But after that, and the conversation goes stale, I would say a statement and try to follow that up with more stuff to say. But the only responses I would get are one word answers like "Yup, Okay, Cool, Wow, etc" When I am doing 90% of the conversation and she barely has anything to ask me, I know I am fucked. Even in a DHV story when I leave parts out so that they can ask me questions and indulge in what I am saying, they never do it, thus leaving me with one word answers.

I tried this routine that if you are stuck after talking up this girl, I would say "Wow I have been talking your ear off, what do you want to know about me?" And most of the time its an "I don't know" answer.

Keeping the conversation going after isolation is real hard. What am I doing wrong/what are some tips?

Try to get her do the talking more, start a conversation that's light, funny maybe. Don't go talking for several minutes then wait for her talk back. Make her feel you want to listen to she has to say. Talk about something funny, or interesting that you experience ans ask her if she had the same. One way or the other, make her be the one who tells the story and you're the one listening.

shouldn't you be kino escalating? 10 mins of comfort may or may not be long enough, but the point of isolation is so that you can get tons of kino and escalte and then bounce or close. If you feel nothing is happening in isolation (like ten mins of you talking her ear off) shouldn't you be suggesting "hey lets go back to our friends" it's the more social thing and you can't get anywhere anyway because you have already tried.
Build up more rapport and attraction and try to isolate later (talk to other girls and see if you get better results from them, she'll notice and you'll have options).

Make her talk. Ask questions that require long replies, usualy if she starts giving one word replies then thats the way the conversation is going to go, unless you do something about it.

apparently the person who didnt talk much liked me the most. wtf? sometimes the game throws me off guard haha. thanks for the advice.