Isolation is just really inconvenient to do during the day. The best you can do is just go for a quick number close. The way to do this would be to create a lot of attraction among everyone in the group. Then get all their numbers. Comfort comes later on the phone. That is your "isolation".
Unless you have a wing, stick with approaching girls who are alone. People have things to do during the day, which means their friends won't just stand there for you to pick up their friend.
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But to pitch in my $0.02, I think if its like a 2 set, do the best friend routine. If its a bigger set, I think an opinion opener then AMOG.
You don't have to. Go direct. Direct approach and daygame were a match made in heaven. The reactions I get from some of the girls is ridiculous. Instant attraction. Indirect game is inefficient during the day.