Hi guys,
if you have ever watched the serie 'Friends', you know that Joey and Chandler are probably best friends and that they are pretty funny together. Yesterday I was at a party, and me and my buddy started asking almost every girl in the place who of us she thinks is Joey and who is Chandler. The girls that know Friends, respond very cool. It makes them laugh, and you can easily start up a conversation from there.
I don't know whether you guys like it or not, but as the title already explained, I never thought this would be a good opener (you can also use it in the middle of a conversation, as you are talking about tv-shows for example). I must say, we were pretty drunk, so maybe they were just amused by us being drunk and asking stupid questions
but next time, I will give it another try and we'll see how it works out 
So give it shot, you never know
Vincent